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68(12):1077-81
Altiratinib dosed at 10 mg/kg twice a day leads to a significant 90% decrease in BLI signal
2017 Jun 13
which was also consistent with predicted clearance using in vitro data from monkey liver microsomes
24(16):3690-9
IMR-1 - CAS# 310456-65-6 Size:10mg solid 68(12):1077-81IMR 1 is a novel class of Notch inhibitors targeting the transcriptional activation with an IC50 of 26 M. IMR 1 prevents the recruitment of Mastermind like 1 (Maml1) to the Notch Ternary Complex (NTC) on chromatin, inhibits Notch target gene transcription and dramatically inhibits tumor growth. Product information CAS Number: 310456 65 6 Molecular Weight: 353. 41 Formula: C15H15NO5S2 Chemical Name: ethyl 2 (2 methoxy 4 {[(5E) 4 oxo 2 sulfanylidene 1,
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