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A recent study shows that induction of autophagy by STF-62247 increases sensitivity of RCC under hypoxic conditions to radiation in a VHL-dependent manner
32-undecone
CAS Number: 844499-71-4
InChi: InChI=1S/C20H32N2O/c1-3-12-21(13-4-1)16-7-17-23-20-10-8-19(9-11-20)18-22-14-5-2-6-15-22/h8-11H
Treshkur T
DCC-2036 t N-oxide A recent study shows thatDCC 2036, is an orally bioavailable small molecule inhibitor of multiple tyrosine kinases with potential antineoplastic activity. Multitargeted tyrosine kinase inhibitor DCC 2036 binds to and inhibits the Bcr Abl fusion oncoprotein by changing the conformation of the folded protein to disallow ligand dependent and ligand independent activation; in addition, this agent binds to and inhibits Src family kinases LYN, HCK and FGR and the receptor tyrosine