The age-Based Dating between Blood circulation pressure and you may Cognitive Disability: A combination-Sectional Analysis in an outlying Part of Xi’an, China

The age-Based Dating between Blood circulation pressure and you may Cognitive Disability: A combination-Sectional Analysis in an outlying Part of Xi’an, China

Blood pressure levels is actually a modifiable exposure grounds to have intellectual impairment, as the relationship between blood pressure levels and you may intellectual impairment isn’t completely know. The objective of this research were to have a look at the outcome away from age for the matchmaking between blood pressure and intellectual handicap.


Blood pressure level and in the world cognitive setting recommendations was compiled away from 1799 members (ages 40–85) just who lived-in a town throughout the suburbs away from Xi’an, China, throughout inside the-people interview. Intellectual impairment try defined as a small-Mental state Test (MMSE) rating less than the fresh cutoff well worth. The end result of age to the relationship anywhere between blood pressure parameters [systolic blood pressure levels (SBP), diastolic blood pressure (DBP), mean arterial blood circulation pressure (MABP), and you can hypertension (HBP, SBP?140 mm Hg and you will/or DBP?90 mm Hg)] and intellectual handicap is actually reviewed by the logistic regression habits using interaction and you may stratified analysis. Blood pressure levels and you may many years was in fact considered one another continuing and you can categorical data.

Overall performance

A total of 231 participants were diagnosed as having cognitive impairment based on our criteria. Interaction analysis for the total population showed that SBP (when regarded as continuous data) was positively correlated with cognitive impairment (OR = 1.130 [95% CI, 1.028–1.242] per 10mmHg, P = 0.011); however, the age by SBP interaction term was negatively correlated with cognitive impairment (OR = 0.989 [95% CI, 0.982–0.997] per 10mmHg?year, P = 0.006), indicating that the relationship between SBP and cognitive impairment was age-dependent (OR = 1.130?0.989 (age-55.5) per 10mmHg,40 ?age?85). When the blood pressure and age were considered as binary data, the results were similar to those obtained when they were considered as continuous variables. Stratified multivariate analysis revealed that the relationship between SBP (when regarded as continuous data) and cognitive impairment was positive for patients aged 40–49 years (OR = 1.349 [95% CI: 1.039–1.753] per 10mmHg, P = 0.025) and 50–59 years (OR = 1.185 [95% CI: 1.028–1.366] per 10mmHg, P = 0.019), whereas it tended to be negative for patients aged 60–69 years (OR = 0.878 [95% CI: 0.729–1.058] per 10mmHg, P = 0.171) and ?70 years (OR = 0.927 [95% CI: 0.772–1.113] per 10mmHg, P = 0.416). Results similar to those for SBP were obtained for DBP, MABP and HBP as well. Subsequently, SBP, DBP and MABP were transformed into categorical data (SBP<140mmHg, 140mmHg?SBP<160mmHg, and SBP?160mmHg; DBP<90mmHg, 90mmHg?DBP<100mmHg, and DBP?100mmHg; MABP<100mmHg, 100mmHg?MABP<110mmHg, and MABP?110mmHg), and the stratified multivariate analysis was repeated. This analysis showed that the age-dependent association continued to exist and was especially prominent in the SBP?160 mmHg, DBP?90 mmHg and MABP?110 mmHg groups.


Hypertension was surely correlated with intellectual disability in the middle-aged, however, that it self-confident connection declines with expanding years. These efficiency showed that certain hypertension management approaches for individuals a long time may be critical for maintaining cognitive vitality.

Citation: Shang S, Li P, Deng Meters, Jiang Y, Chen C, Qu Q (2016) This-Established Relationships ranging from Blood pressure level and Cognitive Disability: A corner-Sectional Study in a rural Area of Xi’an, China. PLoS One eleven(7): e0159485.

Copyright: © 2016 Shang ainsi que al. This really is an open availableness article marketed beneath the regards to the newest Innovative Commons Attribution Licenses, hence permits unrestricted have fun with, delivery, and you can reproduction in just about any average, given the chappy initial creator and you can provider is actually credited.

Analysis Availableness: Due to limitations implemented because of the authorities of your own Mans Republic out-of Asia, analysis can not be generated in public places found in regards to the new Tort Responsibility Rules and you will Statistics Rules. Data accessibility was also restricted by the moral recognition to protect information that is personal of professionals. Some one searching for opening the info have to receive moral acceptance out-of the health Stability Committee of one’s Very first Connected Hospital off Xi’an Jiaotong College (). Requests a de-identified research place from this analysis are sent to related publisher Qiumin Qu () immediately following finding moral acceptance.